The effect of particle size on the toxicity of alpha-naphthyl thiourea (antu) to albino rats.
نویسندگان
چکیده
منابع مشابه
Islands Spark Accelerated Evolution
-Clonogenic growth (colony-forming efficiency, CFE) of i.v. injected allogeneic W256 tumour cells in the lungs was markedly enhanced by treatment of rats with x-naphthyl thiourea (ANTU) injected i.p. from 2 h before to 2 h after the tumour cells. ANTU specifically increases pulmonary vascular permeability in adult rats and causes acute pulmonary oedema and pleural effusion. Inhibition of drug t...
متن کاملStudies on the mechanism of action of thiourea and related compounds; inhibition of oxidative enzymes and oxidations catalyzed by copper.
The recent discovery of the rodenticidal properties of a-naphthylthiourea (ANTU) by Richter (1) has aroused interest in the mechanism by which this compound produces its acute toxic effects in animals. Factors associated with the toxicity of ANTU such as (a) the high toxicity to Norway rats, (b) the lower toxicity to most other species, (c) the development of tolerance after administration of s...
متن کاملStudies on the Mechanism of Action of Thiourea and Related Compounds Ii. Inhibition of Oxidative Enzymes and Oxidations Catalyzed by Copper*
The recent discovery of the rodenticidal properties of a-naphthylthiourea (ANTU) by Richter (1) has aroused interest in the mechanism by which this compound produces its acute toxic effects in animals. Factors associated with the toxicity of ANTU such as (a) the high toxicity to Norway rats, (b) the lower toxicity to most other species, (c) the development of tolerance after administration of s...
متن کاملPulmonary toxicity of thioureas in the rat.
Administration of alpha-naphthylthiourea (ANTU) to rats causes damage to pulmonary endothelial cells and possibly mesothelial lining cells that together may account for the massive pleural effusion characteristic of thiourea toxicity. Using 35S-thiourea as a model compound, the extent of binding of 35S to lung proteins correlated well with the extent of edema, suggesting that the extent of bind...
متن کاملMelatonin and Alpha Lipoic Acid: Possible Mitigants for Lopinavir/Ritonavir- Induced Renal Toxicity in Male Albino Rats
Introduction: This study evaluated the effects of pretreatments with melatonin (MT), and Alpha Lipoic acid (ALA) on lopinavir/ritonavir (LPV/r) -induced serum levels of creatinine (Cr), urea (U), uric acid (Ua) and kidney levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT) in male albino rats. Effects of treatments with MT and ALA were also evaluate...
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ورودعنوان ژورنال:
- The Journal of hygiene
دوره 53 3 شماره
صفحات -
تاریخ انتشار 1955